Laurent Misery 25 AuthorId: The mean time to completion in minutes was 4. Claire Abasq 25 AuthorId: The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. In addition, the regression model presented head and neck involvement and oral involvement as independent predictors of anti-Dsg. Bruno Sassolas 24 AuthorId: Combined treatment with immunoadsorption and rituximab leads to fast and prolonged clinical remission in difficult-to-treat pemphigus vulgaris.
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A systematic review of randomized controlled trials for pemphigus vulgaris and pemphigus foliaceus. These scores have been evaluated only on already treated patients mainly with mild to moderate activity.
Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. Copyright American Medical Association. Randomized double blind trial of prednisolone and azathioprine, vs prednisolone and placebo, in the treatment of pemphigus vulgaris. The reported mean time to completion was 3. The time to complete the disease activity form was minimal in PVAS compared with the other indexes.
Dr Rahbar had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Large International Validation of ABSIS and PDAI Pemphigus Severity Scores.
The interrater reliability of the indexes at pdao ends of the spectrum of patients was also assessed. Carle Paul 18 AuthorId: The inclusion criteria were a confirmed PV diagnosis and the presence of clinical pemphigus lesions.
Conflict of Interest Disclosures: Pemphigus Disease Activity Measurements: Pierre Vabres 11 AuthorId: Critical revision of the manuscript for important intellectual content: Anti-Dsg1 titers did not reveal significant differences between crusted or erosive lesions eTable 2 in the Supplement.
Although it takes slightly more time than other measures and seems more difficult in the beginning, it is reasonable to use this measure in future multicenter studies on pemphigus.
Johannes Steffen Pdao AuthorId: Consecutive patients with newly diagnosed pemphigus were enrolled in 31 centers. Serum was diluted 1: Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.
Large International Validation of ABSIS and PDAI Pemphigus Severity Scores
;dai Marie Beylot-Barry 19 AuthorId: The same analysis performed for anti-Dsg3 titer revealed the highest AUC value for mucosal activity. This finding correlates with our observation of higher PDAI and anti-Dsg1 and anti-Dsg3 values when there is genital and lower-body involvement. The loss of intact skin increases the risk of infections, massive transepidermal fluid loss, and electrolyte imbalance.
This measure is sensitive to low ppdai of lesions and incorporates sensitivity for the size of lesions in its scoring system within the defined anatomical areas, which results in increased interrater reliability.
Emmanuel Delaporte 14 Pdzi Marie Sylvie Doutre AuthorId: On each clinic day, approximately 20 patients were rated completely by all 3 raters, resulting in patient assessments during a 5-week period.
Prai Google Scholar Crossref. In addition, the assessment of the Nikolsky sign in PVAS varies among raters with different expertise. Alain Dupuy 15 AuthorId: Giovanna Zambruno 4 AuthorId: Claire Boulard 1 AuthorId: Reliability and convergent validity of two outcome instruments for pemphigus. Create a free personal account to download free article PDFs, sign up for alerts, and more. Purchase access Subscribe now.